AICAR 100mg Pen
AICAR (5-Aminoimidazole-4-carboxamide ribonucleotide) is a research compound studied for its role in cellular energy regulation, metabolic adaptation, and exercise physiology. It activates AMP-activated protein kinase (AMPK), a key regulator of energy balance, making it valuable for human-relevant studies on metabolism, endurance, and mitochondrial function.
Key Features
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š§Ŗ cGMP manufactured in an FDA-registered facility
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ā ā„98% purity confirmed by HPLC analysis
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š Batch-specific Certificates of Analysis (COAs) included
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š Sterile, lyophilized pens for research use only
Human-Relevant Research Applications
š Exercise and endurance research ā AICAR enhances metabolic pathways that mimic exerciseāinduced AMPK activation, linked to increased endurance in preclinical models. PubMed: https://pubmed.ncbi.nlm.nih.gov/38873554/
𧬠Mitochondrial energy studies ā AICAR activates AMPK, the key regulator of cellular energy homeostasis, supporting efficient energy production and metabolic signaling. PubMed:https://pubmed.ncbi.nlm.nih.gov/34064363/
šŖ Muscle adaptation ā AMPK activation by AICAR can protect muscle from inflammationādriven atrophy and support metabolic resilience during energetic stress. PubMed: https://pubmed.ncbi.nlm.nih.gov/29844217/
Mechanism Summary
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Activates AMPK, a master energy sensor
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Promotes fatty acid oxidation and glucose uptake
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Enhances mitochondrial biogenesis and energy efficiency
Frequently Research Questions
How does AICAR improve endurance research models?
By activating AMPK, AICAR increases cellular energy production and fatty acid oxidation, enhancing exercise capacity.
What is the most relevant metabolic application?
Human-relevant studies focus on glucose regulation, mitochondrial function, and energy adaptation.
Does AICAR influence mitochondrial biogenesis?
Yes. AMPK activation stimulates mitochondrial growth and ATP production efficiency.
Scientific References
McConell et al. (2010) ā āAICAR increases mitochondrial biogenesis in L6 myotubes via AMPKā supports AMPKāmediated mitochondrial effects of AICAR. PubMed: https://pubmed.ncbi.nlm.nih.gov/20044477/
Legal & Research Disclaimer
This material is supplied exclusively for laboratory research use. It is not intended for diagnostic, therapeutic, cosmetic, human, or veterinary applications. The purchaser assumes all responsibility for compliance with applicable local, state, and federal regulations governing research compounds.