MOTS-C Pen
MOTS-C (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a 16-amino acid mitochondrial-derived peptide studied for its role in human metabolic regulation, cellular energy balance, and longevity pathways. MOTS-C is a valuable tool for research into glucose metabolism, insulin sensitivity, exercise performance, and anti-aging cellular mechanisms.
Key Features
๐งช cGMP manufactured in an FDA-registered facility
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โฅ98% purity confirmed by HPLC analysis
๐ Batch-specific Certificates of Analysis (COAs) included
๐ Sterile, lyophilized pens
โก Boosts metabolism & insulin sensitivity
Supports glucose uptake and metabolic efficiency by activating the AMPK energy pathway.
๐ https://pubmed.ncbi.nlm.nih.gov/25738459/
๐ก๏ธ Protects cells from oxidative stress
Helps reduce inflammation and cellular damage linked to stress, aging, and metabolic strain.
๐ https://pubmed.ncbi.nlm.nih.gov/34859377/
๐ Enhances energy & healthy aging
Supports mitochondrial energy balance and physical performance as natural levels decline with age.
๐ https://pubmed.ncbi.nlm.nih.gov/36233287/
Mechanism Summary
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Activates AMPK, a key cellular energy sensor, promoting efficient glucose utilization
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Upregulates GLUT4 translocation, supporting skeletal muscle glucose uptake
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Modulates mitochondrial biogenesis, enhancing ATP production and cellular energy resilience
Frequently Asked Research Questions
How does MOTS-C compare to other metabolic peptides?
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MOTS-C uniquely targets mitochondrial and nuclear gene pathways, whereas most metabolic peptides primarily affect hormonal signaling.
What protocol is most effective for metabolic research?
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Human-relevant studies suggest 0.5โ5 mg/kg subcutaneous dosing for GH-independent metabolic and energy studies.
Can MOTS-C support cognitive or neuroprotective pathways?
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Yes. Studies indicate mitochondrial regulation in neurons, improving energy homeostasis and memory function.
Scientific References
๐งฌ Exercise performance & muscle metabolism
MOTS-C is upregulated by exercise and has been shown to improve physical performance, enhance skeletal muscle metabolism, and increase exercise capacity in animal models โ acting alongside pathways like AMPK and PGC-1ฮฑ that support energy production and adaptation.
๐ https://pubmed.ncbi.nlm.nih.gov/33473109/
๐ช Endurance & mitochondrial function
Endurance training boosts MOTS-C secretion, and higher MOTS-C levels are associated with enhanced mitochondrial respiratory function and greater aerobic exercise capacity, suggesting a role in endurance adaptations.
๐ https://pubmed.ncbi.nlm.nih.gov/39706498/
Legal & Research Disclaimer
This material is supplied exclusively for laboratory research use. It is not intended for diagnostic, therapeutic, cosmetic, human, or veterinary applications. The purchaser assumes all responsibility for compliance with applicable local, state, and federal regulations governing research compounds.