ARA-290

ARA‑290, also known as Cibinetide, is a synthetic peptide derived from erythropoietin (EPO) and engineered to provide tissue‑protective benefits without stimulating red blood cell production. It selectively activates the innate repair receptor (IRR) complex, a signaling pathway involved in reducing inflammation, supporting nerve health, and promoting tissue regeneration.

ARA‑290 has been studied in clinical research for its potential benefits in neuropathic pain, small fiber neuropathy, autoimmune disorders, and chronic inflammatory conditions, making it a compelling peptide for regenerative and functional medicine investigations.

Key Features

🧬 Engineered Tissue‑Protective Peptide — Designed to engage the innate repair receptor without erythropoietic effects.
🔬 Modulates Inflammation & Repair Pathways — Supports cellular resilience and anti‑inflammatory signaling.
🧠 Neuropathy‑Focused Mechanism — Targets nerve signaling pathways associated with pain and sensory function.
✒️ Pre‑filled sterile peptide pens for research use only — High‑purity delivery form for controlled experimental protocols.

Human‑Relevant Research Applications

🔬 Supports nerve function and reduces neuropathic symptoms in humans
A randomized, double‑blind, placebo‑controlled clinical trial in individuals with sarcoidosis‑associated small fiber neuropathy demonstrated that ARA‑290 significantly improved neuropathic pain and small nerve fiber function compared with placebo, highlighting its relevance in human neuropathy research.🔗 https://pubmed.ncbi.nlm.nih.gov/19927000/

Key Benefits

✨ Supports Neuropathy Relief – Clinical evidence suggests ARA‑290 can improve symptoms of small fiber neuropathy and associated pain.

🛡️ Modulates Inflammatory Responses – Activates innate repair pathways linked to reduced chronic inflammation.

🧠 Promotes Nerve Health & Regeneration – Engages IRR signaling to support nerve resilience and function.

⚖️ Non‑Erythropoietic Design – Engineered to provide tissue protection without increasing red blood cell production.

💪 Translational Research Utility – Valuable for investigational studies in autoimmune, inflammatory, and regenerative contexts.

Reconstitution & Handling Guidance

1️⃣ Use sterile bacteriostatic water (0.9% benzyl alcohol)
2️⃣ Add 3 ml of bacteriostatic water to reconstitute the peptide
3️⃣ Gently swirl until fully dissolved (do not vortex)
4️⃣ Store reconstituted peptide at 4 °C–10 °C for 2–3 months
5️⃣ Unreconstituted peptide can be stored at 4 °C–10 °C until the expiration date

Mechanism Summary

• Innate Repair Receptor Activation — ARA‑290 selectively engages the IRR complex, initiating anti‑inflammatory and cytoprotective signaling.
• Neuropathy Pathway Support — Modulates pathways involved in nerve signaling and small fiber function, correlating with improved clinical outcomes in neuropathic pain models.
• Tissue Protection & Regeneration — Supports cellular resilience and repair mechanisms in chronic inflammatory and autoimmune research frameworks.