AICAR

AICAR (5-Aminoimidazole-4-carboxamide ribonucleotide) is a well-characterized AMPK activator originally developed for metabolic and cardiovascular research. By activating AMP-activated protein kinase (AMPK) — the body’s central cellular energy sensor — AICAR mimics key molecular effects of exercise, influencing glucose uptake, fat oxidation, and energy balance.

Due to AMPK’s central role in mitochondrial function and metabolic health, AICAR has gained interest in performance optimization, metabolic regulation, and longevity-focused research models.

Key Features

🧫 cGMP manufactured in an FDA-registered facility
✔️ ≥98% purity verified by HPLC analysis
📑 Batch-specific Certificates of Analysis (COAs) included
💉 Sterile, lyophilized vials for research use only

Human-Relevant Research Applications

🔥 AMPK activation & metabolic regulation in humans
Human research confirms that AICAR directly activates AMPK in skeletal muscle, triggering downstream pathways involved in energy balance, fat metabolism, and metabolic adaptation.
🔗 https://pubmed.ncbi.nlm.nih.gov/16176927/

🍬 Enhanced glucose uptake & insulin-independent pathways
Studies in human muscle tissue demonstrate that AICAR stimulates glucose uptake via AMPK activation independently of insulin, highlighting its relevance for metabolic and glycaemic research.
🔗 https://pubmed.ncbi.nlm.nih.gov/11818544/

⚙️ Mitochondrial biogenesis & cellular energy signaling
AMPK activation through agents like AICAR is strongly linked in human metabolic research to improved mitochondrial signaling and oxidative metabolism — mechanisms central to endurance and longevity research.
🔗 https://pubmed.ncbi.nlm.nih.gov/19332493/

Mechanism Summary

• Activates AMP-activated protein kinase (AMPK), the master regulator of cellular energy status

• Promotes glucose uptake through insulin-independent pathways

• Enhances fat oxidation and metabolic efficiency

• Supports mitochondrial signaling pathways associated with metabolic health and aging

• Provides a translational model for studying exercise-mimetic cellular responses

   

  Reconstitution & Handling Guidance

  1️⃣ Use sterile bacteriostatic water (0.9% benzyl alcohol)
  2️⃣ Add 3 ml of bacteriostatic water to reconstitute the peptide
  3️⃣ Gently swirl until fully dissolved (do not vortex)
  4️⃣ Store reconstituted peptide at 4 °C–10 °C for 2–3 months
  5️⃣ Unreconstituted peptide may be stored at 4 °C–10 °C until the expiration date

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  Legal & Research Disclaimer

  This material is supplied exclusively for laboratory research use. It is not intended for diagnostic, therapeutic, cosmetic, human, or veterinary applications. The purchaser assumes all responsibility for compliance with applicable local, state, and federal regulations governing research compounds.