SS-31 Pen

SS‑31, also known as Elamipretide, is a mitochondria‑targeted tetrapeptide designed to protect and restore mitochondrial function — the energy‑producing core of human cells. By selectively binding to cardiolipin in the inner mitochondrial membrane, SS‑31 helps stabilize mitochondrial structure, reduce oxidative stress, and support efficient adenosine triphosphate (ATP) production — the primary energy currency of cells.

These actions make SS‑31 a compelling investigational peptide in research on energy decline, aging‑related mitochondrial dysfunction, cardiovascular energetics, and conditions involving impaired cellular bioenergetics.

Key Features

🔬 cGMP manufactured in an FDA‑registered facility
📈 ≥98% purity confirmed by HPLC analysis
📄 Batch‑specific Certificates of Analysis (COAs) included
💉 Pre‑filled sterile peptide pens for research use only

Human‑Relevant Research Applications

⚡ Improves mitochondrial energetics in human tissues
Ex‑vivo studies using failing human heart tissue have shown that Elamipretide enhances mitochondrial respiratory supercomplex activity, improving oxygen flux and markers of electron transport efficiency in diseased human myocardium.
🔗 https://pubmed.ncbi.nlm.nih.gov/PMC6488757/

🔋 Elevates mitochondrial ATP production in older adults
A randomized trial in aging human skeletal muscle demonstrated that Elamipretide increases mitochondrial ATP production capacity (ATPmax) after a single infusion — the first pharmacologic evidence of acute improvement in human mitochondrial energetics in vivo.
🔗 https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0253849

🧬 Clinically approved cardiolipin‑targeted mitochondrial therapy
Elamipretide (brand name FORZINITY™) has been granted accelerated approval by the U.S. FDA for the treatment of Barth syndrome — a rare mitochondrial disorder characterized by impaired cardiolipin metabolism and compromised energy production.
🔗 https://pubmed.ncbi.nlm.nih.gov/32273339/

Key Benefits of SS‑31

⚡ Supports Mitochondrial Energy Production – Enhances ATP generation by stabilizing the inner mitochondrial membrane and optimizing electron transport chain function.

🛡️ Reduces Oxidative Stress – Lowers mitochondrial reactive oxygen species (ROS), protecting cells from oxidative damage and age-related mitochondrial decline.

💪 Promotes Cellular Resilience – Maintains mitochondrial integrity under metabolic stress, supporting tissue energy capacity and organ function.

❤️ Investigational Cardiovascular Support – Clinically relevant in studies of cardiac bioenergetics, showing potential benefits in conditions with mitochondrial dysfunction.

🧬 Aging & Longevity Research – Studied for its translational potential in age-associated energy decline, neurodegeneration, and systemic mitochondrial dysfunction.

Mechanism Summary

• Selectively binds to cardiolipin in the inner mitochondrial membrane to support structural integrity and electron transport stability
• Enhances mitochondrial respiration and ATP generation by improving coupling efficiency within the electron transport chain
• Reduces pathological reactive oxygen species production linked to mitochondrial dysfunction in disease states
• Supports translational research into aging‑related bioenergetic decline, muscle weakness syndromes, and mitochondrial myopathies